Octulose, about to get bigger?

What is octulose? And why is it about to be bigger? Well, according to Qingwei Zhang and Dorothea Bartels, it’s a “forgotten metabolite”. Yes, but what is it?

Octulose is an 8-carbon sugar that occurs in plants (especially so-called resurrection plants such as Craterostigma, bacteria, yeast and animals. However, although its existence has been known for approx. 70 years, study of its metabolic role has apparently largely been neglected, i.e. it’s been ‘forgotten’. But, since it has a defined chemical formula – C8 H16 O8 – how can it be made ‘bigger’?

Craterostigma plantagineum
Craterostigma_plantagineum. Image: JMK / Wikipedia

That’s down to the efforts of Zhang and Bartels, who attempt to ‘big up’ this diminutive organic compound in their Viewpoint item. In particular, they emphasise possible commercial value from exploitation of the compound. For example, they note that it may have a role as an antioxidant, and could be a potential target for developing new drugs against disease-causing parasites such as Trypanosoma brucei (causative agent of African Trypanosomiasis, more widely known as Sleeping Sickness), Trypanosoma cruzi (which causes American Trypanosomiasis, also known as Chagas Disease), and various Leishmania species (which cause Leishmaniasis).

Somewhat towards the other end of the spectrum of ‘worthiness of projects’, octulose derivatives may also have value for developingcosmetics. Maybe, after three-score and ten years, it’s now time for octulose to ‘shine’* after all? Never heard of octulose before? You have now!

* But, hopefully, in a manner unlike Mélanie René’s song of the same name that failed to qualify for the final as Switzerland’s entry for the Eurovision Song Contest 2015…

Further reading

Zhang, Q., & Bartels, D. (2017). Octulose: a forgotten metabolite? Journal of Experimental Botany, 68(21-22), 5689–5694. https://doi.org/10.1093/jxb/erx367

Zhang, Q., Song, X., & Bartels, D. (2016). Enzymes and Metabolites in Carbohydrate Metabolism of Desiccation Tolerant Plants. Proteomes, 4(4), 40. https://doi.org/10.3390/proteomes4040040