January 31, 2017

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  • The model of centromere drive in monocentric chromosomes and its suppression by chromosomal holokinetism.
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    Holokinetic chromosomes beat selfish centromeres

    In eukaryotic lineages with monocentric chromosomes, centromeres and centromeric histone H3 (CENH3) undergo a recurrent evolutionary conflict, whereby selfish centromeres subvert female meiosis, and CENH3 evolves adaptively to counterbalance the deleterious consequences of centromere drive. Positively selected CENH3 can therefore provide an indication as to whether this evolutionary arms race has occurred in a given […] More